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Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Wang, Yingcai; Zhu, Jiang; Liu, Jiwen Jim; Chen, Xiaoqi; Mihalic, Jeff; Deignan, Jeffrey; Yu, Ming; Sun, Daqing; Kayser, Frank; McGee, Lawrence R; Lo, Mei-Chu; Chen, Ada; Zhou, Jing; Ye, Qiuping; Huang, Xin; Long, Alexander M; Yakowec, Peter; Oliner, Jonathan D; Olson, Steven H; Medina, Julio C.
Affiliation
  • Wang Y; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Zhu J; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. Electronic address: jiangz@amgen.com.
  • Liu JJ; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Chen X; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Mihalic J; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Deignan J; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Yu M; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Sun D; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Kayser F; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • McGee LR; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Lo MC; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Chen A; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Zhou J; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Ye Q; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Huang X; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, USA.
  • Long AM; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, USA.
  • Yakowec P; Department of Therapeutic Discovery, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, USA.
  • Oliner JD; Department of Oncology Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
  • Olson SH; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
  • Medina JC; Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 24(16): 3782-5, 2014 Aug 15.
Article in En | MEDLINE | ID: mdl-25042256
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Full text: 1 Database: MEDLINE Main subject: Piperidones / Sulfonamides / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Drug Discovery / Acetates Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Piperidones / Sulfonamides / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Drug Discovery / Acetates Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article Affiliation country: United States