PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.

Pedersen, Christian Spang; Sørensen, Dorte Bratbo; Parachikova, Anna I; Plath, Niels

Pedersen, Christian Spang; Sørensen, Dorte Bratbo; Parachikova, Anna I; Plath, Niels.

Affiliation

Pedersen CS; Synaptic Transmission, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark. Electronic address: Chsp@lundbeck.com.
Sørensen DB; Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C., Denmark.
Parachikova AI; Synaptic Transmission, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.
Plath N; Synaptic Transmission, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.

Behav Brain Res ; 273: 63-72, 2014 Oct 15.

Article in En | MEDLINE | ID: mdl-25064467

Subject(s)

Behavior, Animal/drug effects; Disease Models, Animal; Excitatory Amino Acid Antagonists/toxicity; Phencyclidine/toxicity; Schizophrenia/chemically induced; Schizophrenic Psychology; Animals; Antipsychotic Agents/pharmacology; Benzofurans/pharmacology; Hyperkinesis/chemically induced; Male; Mice; Mice, Inbred C57BL; Quinuclidines/pharmacology; Rotarod Performance Test; Social Behavior; Thiophenes/pharmacology

Key words

EVP-6124; Nest building test (NEST); Schizophrenia; Social interaction test (SIT); Sub-chronic PCP; TC-5619

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Full text: 1 Database: MEDLINE Main subject: Phencyclidine / Schizophrenia / Schizophrenic Psychology / Behavior, Animal / Excitatory Amino Acid Antagonists / Disease Models, Animal Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Behav Brain Res Year: 2014 Type: Article

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