Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.

Chen, Yaoyu; Peng, Cong; Abraham, Sheela A; Shan, Yi; Guo, Zhiru; Desouza, Ngoc; Cheloni, Giulia; Li, Dongguang; Holyoake, Tessa L; Li, Shaoguang

Chen, Yaoyu; Peng, Cong; Abraham, Sheela A; Shan, Yi; Guo, Zhiru; Desouza, Ngoc; Cheloni, Giulia; Li, Dongguang; Holyoake, Tessa L; Li, Shaoguang.

J Clin Invest ; 124(9): 3847-62, 2014 Sep.

Article in En | MEDLINE | ID: mdl-25105362

Subject(s)

Arachidonate 15-Lipoxygenase/physiology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Neoplastic Stem Cells/physiology; Animals; Apoptosis; Arachidonate 15-Lipoxygenase/genetics; Cell Line, Tumor; Cells, Cultured; Fluorenes/pharmacology; Fusion Proteins, bcr-abl/physiology; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/etiology; Lipoxygenase Inhibitors/pharmacology; Mice; Mice, Inbred C57BL; P-Selectin/physiology

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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Arachidonate 15-Lipoxygenase / Leukemia, Myelogenous, Chronic, BCR-ABL Positive Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2014 Type: Article

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