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Two novel toxin variants revealed by whole-genome sequencing of 175 Clostridium botulinum type E strains.
Weedmark, K A; Lambert, D L; Mabon, P; Hayden, K L; Urfano, C J; Leclair, D; Van Domselaar, G; Austin, J W; Corbett, C R.
Affiliation
  • Weedmark KA; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Lambert DL; Bureau of Microbial Hazards, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.
  • Mabon P; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Hayden KL; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Urfano CJ; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Leclair D; Bureau of Microbial Hazards, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.
  • Van Domselaar G; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
  • Austin JW; Bureau of Microbial Hazards, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.
  • Corbett CR; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada cindi.corbett@phac-aspc.gc.ca.
Appl Environ Microbiol ; 80(20): 6334-45, 2014 Oct.
Article in En | MEDLINE | ID: mdl-25107978
ABSTRACT
We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay.
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Full text: 1 Database: MEDLINE Main subject: Botulinum Toxins / Clostridium botulinum type E Limits: Animals Country/Region as subject: America do norte Language: En Journal: Appl Environ Microbiol Year: 2014 Type: Article Affiliation country: Canada
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Full text: 1 Database: MEDLINE Main subject: Botulinum Toxins / Clostridium botulinum type E Limits: Animals Country/Region as subject: America do norte Language: En Journal: Appl Environ Microbiol Year: 2014 Type: Article Affiliation country: Canada