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Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls.
Zhao, Y; Gui, Z L; Liao, S; Gao, F; Ge, Y Z; Jia, R P.
Affiliation
  • Zhao Y; Department of Urology, Xuzhou 3th Hospital, Affiliated Hospital of Jiangsu University, Xuzhou, China.
  • Gui ZL; Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  • Liao S; Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  • Gao F; Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  • Ge YZ; Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  • Jia RP; Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China 601127797@qq.com.
Genet Mol Res ; 13(3): 5534-40, 2014 Jul 25.
Article in En | MEDLINE | ID: mdl-25117309
Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that included 9617 cases and 16,323 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Our meta-analysis showed that, overall, the rs2294008 (C>T) polymorphism was associated with bladder cancer susceptibility (OR = 1.29, 95%CI = 1.20-1.40 for TT vs CC; OR = 1.24, 95%CI = 1.16-1.31 for CT vs CC; OR = 1.25, 95%CI = 1.18-1.33 for TT/CT vs CC; OR = 1.13, 95%CI = 1.06-1.20 for TT vs CT/CC). In the stratified analyses, the risk remained significant for studies of European populations, Asian populations, population-based studies, and hospital-based studies. In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Antigens, Neoplasm / Neoplasm Proteins Type of study: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Humans / Male Language: En Journal: Genet Mol Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2014 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Antigens, Neoplasm / Neoplasm Proteins Type of study: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Humans / Male Language: En Journal: Genet Mol Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2014 Type: Article Affiliation country: China