Glutamine-supplemented total parenteral nutrition improves gut immune function.
Arch Surg
; 124(12): 1396-9, 1989 Dec.
Article
in En
| MEDLINE
| ID: mdl-2511819
ABSTRACT
Glutamine has been demonstrated to be an important source of fuel for the gut. The purpose of this study was to evaluate the effect of glutamine-supplemented hyperalimentation on gut immune function. Thirty-six female Fischer rats were randomized into three groups group 1 (chow) was fed rat chow and water ad libitum, group 2 (total parenteral nutrition) received a standard hyperalimentation formula, and group 3 (total parenteral nutrition-glutamine) received a hyperalimentation solution that contained 2% glutamine. Animals were maintained on their respective diets for 2 weeks and then killed. Mesenteric lymph nodes were harvested for culture, bile was assayed for secretory IgA, and bowel was excised to assay bacterial adherence. Results indicated that glutamine-supplemented total parenteral nutrition protects against bacterial translocation from the gut seen with standard formulas. This effect may be mediated by the secretory IgA immune system.
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Database:
MEDLINE
Main subject:
Immunoglobulin A, Secretory
/
Parenteral Nutrition, Total
/
Glutamine
/
Intestines
Limits:
Animals
Language:
En
Journal:
Arch Surg
Year:
1989
Type:
Article