Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.

Lee, Sukjun; Lim, Donghyun; Lee, Eunyoung; Lee, Nakyung; Lee, Hong-Gun; Cechetto, Jonathan; Liuzzi, Michel; Freitas-Junior, Lucio H; Song, Jin Sook; Bae, Myung Ae; Oh, Sangmi; Ayong, Lawrence; Park, Seung Bum

Lee, Sukjun; Lim, Donghyun; Lee, Eunyoung; Lee, Nakyung; Lee, Hong-Gun; Cechetto, Jonathan; Liuzzi, Michel; Freitas-Junior, Lucio H; Song, Jin Sook; Bae, Myung Ae; Oh, Sangmi; Ayong, Lawrence; Park, Seung Bum.

Affiliation

Lee S; Early Discovery Program, Institut Pasteur Korea , Seongnam-si, Gyeonggi-do 463-400, Korea.

J Med Chem ; 57(17): 7425-34, 2014 Sep 11.

Article in En | MEDLINE | ID: mdl-25137549

Subject(s)

Antimalarials/pharmacology; Life Cycle Stages/drug effects; Plasmodium falciparum/drug effects; Pyrimidines/pharmacology; Animals; Antimalarials/chemistry; Antimalarials/pharmacokinetics; Area Under Curve; Cell Line, Tumor; Cell Survival/drug effects; Drug Discovery; Drug Evaluation, Preclinical; Hep G2 Cells; Host-Parasite Interactions/drug effects; Humans; Malaria/parasitology; Malaria/prevention & control; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Models, Chemical; Molecular Structure; Plasmodium chabaudi/drug effects; Plasmodium chabaudi/physiology; Plasmodium falciparum/growth & development; Pyrimidines/chemistry; Pyrimidines/pharmacokinetics; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Pyrimidines / Life Cycle Stages / Antimalarials Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Type: Article

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