In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase.

Guo, Jian; Joubran, Camil; Luzietti, Ricardo A; Zhou, Fei; Basarab, Gregory S; Vishwanathan, Karthick

Guo, Jian; Joubran, Camil; Luzietti, Ricardo A; Zhou, Fei; Basarab, Gregory S; Vishwanathan, Karthick.

Affiliation

Guo J; Department of DMPK AstraZeneca Pharmaceuticals, Waltham, MA, USA.

Xenobiotica ; 45(2): 158-70, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25142218

Subject(s)

Barbiturates/pharmacokinetics; DNA Gyrase/pharmacokinetics; Hepatocytes/metabolism; Spiro Compounds/pharmacokinetics; Topoisomerase Inhibitors/pharmacokinetics; Animals; Barbiturates/chemistry; Biotransformation; DNA Gyrase/chemistry; Dogs; Humans; Intestinal Mucosa/metabolism; Mice; Microsomes/metabolism; Rats; Spiro Compounds/chemistry; Topoisomerase Inhibitors/chemistry

Key words

AZ11; excretion; mass spectrometry; metabolism

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Full text: 1 Database: MEDLINE Main subject: Spiro Compounds / Barbiturates / Hepatocytes / DNA Gyrase / Topoisomerase Inhibitors Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2015 Type: Article Affiliation country: United States

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