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Ultrasound Findings of Intraductal Papillary Neoplasm in Bile Duct and the Added Value of Contrast-Enhanced Ultrasound.
Liu, L N; Xu, H X; Zheng, S G; Sun, L P; Guo, L H; Zhang, Y F; Xu, J M; Liu, C; Xu, X H.
Affiliation
  • Liu LN; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Xu HX; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Zheng SG; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Sun LP; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Guo LH; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Zhang YF; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Xu JM; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Liu C; Department of Medical Ultrasound, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
  • Xu XH; Department of Ultrasound, Guangdong Medical College Affiliated Hospital, Zhanjiang, China.
Ultraschall Med ; 36(6): 594-602, 2015 Dec.
Article in En | MEDLINE | ID: mdl-25188491
PURPOSE: To investigate the imaging features of intraductal papillary neoplasm in bile duct (IPNB) on baseline ultrasound and contrast-enhanced ultrasound (CEUS). MATERIALS AND METHODS: The imaging features on baseline ultrasound and CEUS in 16 pathologically proven IPNB lesions in 15 patients were retrospectively analyzed. Real-time contrast specific modes and contrast agent of SonoVue were used for CEUS. RESULTS: Bile duct dilation was present in all patients. The mean lengths for the intraductal papillary adenomas and adenocarcinomas were 2.5 ± 1.1 (range, 1.2 - 4.2 cm) and 5.6 ±â€Š2.0 cm (range, 3.3 - 9.8 cm) (P = 0.004). Three imaging types of IPNB on ultrasound were depicted: bile duct dilation with intraductal mass (n = 8), bile duct dilation without intraductal mass (n = 3), and cystic-solid mixed type (n = 5). On CEUS, solid components of 13 lesions appeared hyper- (n = 12) or iso-enhancement (n = 1) in the arterial phase whereas all showed hypo-enhancement in the portal and late phases. For 3 lesions of bile duct dilation without intraductal mass, CEUS showed non-enhancement during all phases. Pre-surgical CEUS and conventional ultrasound made correct diagnoses in 12 (75.0 %) and 5(31.3 %) of 16 IPNBs respectively (P = 0.04). For CECT, correct diagnosis was also achieved in 12 (75.0 %) of 16 lesions (P = 1.00, in comparison with CEUS). CONCLUSIONS: IPNB should be taken into consideration when intraductal mass or cystic-solid mass with bile duct dilation, or remarkable bile duct dilation without intraductal mass, are found on US. Intraductal mass length > 3.0 cm is more commonly found in malignant IPNB. CEUS might facilitate the diagnosis of IPNB by easily excluding the possibility of commonly found sludge, nonshadowing stones, or blood clots.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Phospholipids / Sulfur Hexafluoride / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Image Enhancement / Carcinoma, Papillary / Adenoma / Common Bile Duct Neoplasms / Contrast Media Type of study: Diagnostic_studies / Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Ultraschall Med Year: 2015 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Phospholipids / Sulfur Hexafluoride / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Image Enhancement / Carcinoma, Papillary / Adenoma / Common Bile Duct Neoplasms / Contrast Media Type of study: Diagnostic_studies / Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Ultraschall Med Year: 2015 Type: Article Affiliation country: China