Efficacy of CPX-351, (cytarabine:daunorubicin) liposome injection, against acute lymphoblastic leukemia (ALL) xenograft models of the Pediatric Preclinical Testing Program.

Carol, Hernan; Fan, Mannie M Y; Harasym, Troy O; Boehm, Ingrid; Mayer, Lawrence D; Houghton, Peter; Smith, Malcolm A; Lock, Richard B

Carol, Hernan; Fan, Mannie M Y; Harasym, Troy O; Boehm, Ingrid; Mayer, Lawrence D; Houghton, Peter; Smith, Malcolm A; Lock, Richard B.

Affiliation

Carol H; Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, NSW, Australia.

Pediatr Blood Cancer ; 62(1): 65-71, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25203866

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Child; Child, Preschool; Cytarabine/administration & dosage; Daunorubicin/administration & dosage; Female; Humans; Liposomes; Male; Maximum Tolerated Dose; Mice; Mice, Inbred NOD; Mice, SCID; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology; Tissue Distribution; Treatment Outcome; Xenograft Model Antitumor Assays

Key words

CPX-351; acute leukemia; efficacy; pharmacokinetics; synergy

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Full text: 1 Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Clinical_trials Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2015 Type: Article Affiliation country: Australia

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