The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU.
J Biol Chem
; 289(46): 31856-31865, 2014 Nov 14.
Article
in En
| MEDLINE
| ID: mdl-25204651
ABSTRACT
The p38 pathway is an evolutionarily conserved signaling pathway that responds to a variety of stresses. However, the underlying mechanisms are largely unknown. In the present study, we demonstrate that p38b is a major p38 MAPK involved in the regulation of oxidative stress tolerance in addition to p38a and p38c in Drosophila. We further show the importance of MK2 as a p38-activated downstream kinase in resistance to oxidative stresses. Furthermore, we identified the iron-sulfur cluster scaffold protein IscU as a new substrate of MK2 both in Drosophila cells and in mammalian cells. These results imply a new mechanistic connection between the p38 pathway and mitochondria iron-sulfur clusters.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Protein Serine-Threonine Kinases
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Oxidative Stress
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MAP Kinase Signaling System
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Drosophila Proteins
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Mitochondrial Proteins
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Intracellular Signaling Peptides and Proteins
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Iron-Sulfur Proteins
Limits:
Animals
/
Humans
Language:
En
Journal:
J Biol Chem
Year:
2014
Type:
Article
Affiliation country:
China