Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.
Annu Rev Cell Dev Biol
; 30: 255-89, 2014.
Article
in En
| MEDLINE
| ID: mdl-25288114
ABSTRACT
In the 1980s, exosomes were described as vesicles of endosomal origin secreted from reticulocytes. Interest increased around these extracellular vesicles, as they appeared to participate in several cellular processes. Exosomes bear proteins, lipids, and RNAs, mediating intercellular communication between different cell types in the body, and thus affecting normal and pathological conditions. Only recently, scientists acknowledged the difficulty of separating exosomes from other types of extracellular vesicles, which precludes a clear attribution of a particular function to the different types of secreted vesicles. To shed light into this complex but expanding field of science, this review focuses on the definition of exosomes and other secreted extracellular vesicles. Their biogenesis, their secretion, and their subsequent fate are discussed, as their functions rely on these important processes.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cell Communication
/
Transport Vesicles
/
Cell-Derived Microparticles
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Cell Dev Biol
Journal subject:
BIOLOGIA
Year:
2014
Type:
Article