Activation of Syk in peripheral blood B cells in patients with rheumatoid arthritis: a potential target for abatacept therapy.

Iwata, Shigeru; Nakayamada, Shingo; Fukuyo, Shunsuke; Kubo, Satoshi; Yunoue, Naoki; Wang, Sheau-Pey; Yoshikawa, Maiko; Saito, Kazuyoshi; Tanaka, Yoshiya

Iwata, Shigeru; Nakayamada, Shingo; Fukuyo, Shunsuke; Kubo, Satoshi; Yunoue, Naoki; Wang, Sheau-Pey; Yoshikawa, Maiko; Saito, Kazuyoshi; Tanaka, Yoshiya.

Affiliation

Iwata S; University of Occupational and Environmental Health Japan, Kitakyushu, Japan.

Arthritis Rheumatol ; 67(1): 63-73, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25303149

Subject(s)

Antirheumatic Agents/therapeutic use; Arthritis, Rheumatoid/drug therapy; Arthritis, Rheumatoid/metabolism; B-Lymphocytes/metabolism; Immunoconjugates/therapeutic use; Receptor Protein-Tyrosine Kinases/metabolism; Abatacept; Aged; Antirheumatic Agents/pharmacology; Arthritis, Rheumatoid/pathology; B-Lymphocytes/drug effects; B-Lymphocytes/pathology; Case-Control Studies; Cell Communication/drug effects; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Female; Humans; Immunoconjugates/pharmacology; Male; Middle Aged; Phosphorylation/drug effects; Severity of Illness Index; T-Lymphocytes, Helper-Inducer/drug effects; T-Lymphocytes, Helper-Inducer/pathology; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Arthritis, Rheumatoid / B-Lymphocytes / Receptor Protein-Tyrosine Kinases / Immunoconjugates / Antirheumatic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Arthritis Rheumatol Year: 2015 Type: Article Affiliation country: Japan

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