Acids/metabolism; Chloride Channels/metabolism; Ion Channel Gating/physiology; Androstadienes/pharmacology; Animals; CHO Cells; Cell Line; Cell Line, Tumor; Cells, Cultured; Chloride Channels/genetics; Cricetinae; Cricetulus; Genistein/pharmacology; HEK293 Cells; Humans; Hydrazones/pharmacology; Hydrogen-Ion Concentration; Ion Channel Gating/genetics; Membrane Potentials/drug effects; Membrane Potentials/genetics; Membrane Potentials/physiology; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation/drug effects; Protein Kinase Inhibitors/pharmacology; RNA Interference; Wortmannin