Synthetic lethal vulnerabilities of cancer.

Fece de la Cruz, Ferran; Gapp, Bianca V; Nijman, Sebastian M B

Fece de la Cruz, Ferran; Gapp, Bianca V; Nijman, Sebastian M B.

Affiliation

Fece de la Cruz F; CeMM - Research Center for Molecular Medicine of the Austrian Academy of Sciences, A1090 Vienna, Austria; email: snijman@cemm.oeaw.ac.at.

Annu Rev Pharmacol Toxicol ; 55: 513-31, 2015.

Article in En | MEDLINE | ID: mdl-25340932

Subject(s)

Antineoplastic Agents/therapeutic use; Biomarkers, Tumor/genetics; Drug Design; Gene Expression Regulation, Neoplastic/drug effects; Genetic Therapy/methods; Molecular Targeted Therapy/methods; Neoplasms/therapy; Animals; Biomarkers, Tumor/metabolism; Cell Death/drug effects; Epigenesis, Genetic/drug effects; Gene Regulatory Networks/drug effects; Humans; Neoplasms/genetics; Neoplasms/metabolism; Neoplasms/pathology; Signal Transduction/drug effects; Translational Research, Biomedical

Key words

clinical translation; drugs; genetic screens; synthetic lethality

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Full text: 1 Database: MEDLINE Main subject: Drug Design / Genetic Therapy / Biomarkers, Tumor / Gene Expression Regulation, Neoplastic / Molecular Targeted Therapy / Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Annu Rev Pharmacol Toxicol Year: 2015 Type: Article

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