Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis.
Mol Med Rep
; 11(2): 1528-34, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-25352049
ABSTRACT
Determination of disease activity in patients with rheumatoid arthritis (RA) has become an important component for RA management. The aim of the present study was to investigate the association between circulating levels of serum amyloid A (SAA) and disease activity in RA patients. The types of disease and the respective number of patients enrolled in the present study were as follows RA, 88; osteoarthritis (OA), 54; systemic lupus erythematosus (SLE), 43; and other autoimmune diseases, 30, as well as 50 healthy controls (HC). SAA levels were measured using an ELISA assay and western blot analysis was used to detect serum SAA levels. The correlations between SAA levels and disease activity score for 28 joints (DAS28), erythrocyte sedimentation rate (ESR) and Creactive protein (CRP), respectively, were evaluated; in addition, the presence and absence of rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (antiCCP) were detected in respect to SAA levels. The results of the present study demonstrated that serum levels of SAA in RA patients were significantly increased compared to those of the OA, SLE, others and HC patients (P<0.05). SAA levels were found to be positively correlated with DAS28, ESR and CRP levels (R2=0.6174, 0.4422 and 0.3919, respectively). In addition, antiCCP was not correlated with DAS28 (R2=0.0154). Furthermore, increased SAA levels were detected in patients with positive antiCCP compared with those in antiCCP negative subjects (P<0.01). In conclusion, the results of the present study provided further evidence for possible roles of SAA in RA, which indicated that it may be a useful biomarker for assessing disease severity and may provide additional information about disease activity.
Full text:
1
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
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Autoantibodies
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Serum Amyloid A Protein
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Acute-Phase Proteins
Type of study:
Risk_factors_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Middle aged
Language:
En
Journal:
Mol Med Rep
Year:
2015
Type:
Article