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Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines.
Driscoll, Denise L; Chakravarty, Arijit; Bowman, Doug; Shinde, Vaishali; Lasky, Kerri; Shi, Judy; Vos, Tricia; Stringer, Bradley; Amidon, Ben; D'Amore, Natalie; Hyer, Marc L.
Affiliation
  • Driscoll DL; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Chakravarty A; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Bowman D; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Shinde V; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Lasky K; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Shi J; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Vos T; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Stringer B; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Amidon B; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • D'Amore N; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
  • Hyer ML; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America.
PLoS One ; 9(11): e111060, 2014.
Article in En | MEDLINE | ID: mdl-25365521
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Full text: 1 Database: MEDLINE Main subject: DNA Damage / Proto-Oncogene Proteins / Cellular Senescence / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Protein Kinase Inhibitors / Mitosis Type of study: Etiology_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: DNA Damage / Proto-Oncogene Proteins / Cellular Senescence / Protein Serine-Threonine Kinases / Cell Cycle Proteins / Protein Kinase Inhibitors / Mitosis Type of study: Etiology_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: United States