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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Olivier, Nelson B; Altman, Roger B; Noeske, Jonas; Basarab, Gregory S; Code, Erin; Ferguson, Andrew D; Gao, Ning; Huang, Jian; Juette, Manuel F; Livchak, Stephania; Miller, Matthew D; Prince, D Bryan; Cate, Jamie H D; Buurman, Ed T; Blanchard, Scott C.
Affiliation
  • Olivier NB; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Altman RB; Department of Physiology and Biophysics & the Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, New York, NY 10065;
  • Noeske J; Department of Molecular Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, CA 94720; and.
  • Basarab GS; Departments of Chemistry and.
  • Code E; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Ferguson AD; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Gao N; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Huang J; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Juette MF; Department of Physiology and Biophysics & the Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, New York, NY 10065;
  • Livchak S; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Miller MD; Departments of Chemistry and.
  • Prince DB; Discovery Sciences, AstraZeneca R&D Boston, Waltham, MA 02451;
  • Cate JH; Department of Molecular Cell Biology, California Institute of Quantitative Biosciences, University of California, Berkeley, CA 94720; and.
  • Buurman ET; Biosciences, Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA 02451 scb2005@med.cornell.edu Ed.Buurman@astrazeneca.com.
  • Blanchard SC; Department of Physiology and Biophysics & the Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medical College, New York, NY 10065; scb2005@med.cornell.edu Ed.Buurman@astrazeneca.com.
Proc Natl Acad Sci U S A ; 111(46): 16274-9, 2014 Nov 18.
Article in En | MEDLINE | ID: mdl-25368144
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Full text: 1 Database: MEDLINE Main subject: Ribosomes / RNA, Bacterial / RNA, Ribosomal, 16S / Escherichia coli / Anti-Bacterial Agents Type of study: Prognostic_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Ribosomes / RNA, Bacterial / RNA, Ribosomal, 16S / Escherichia coli / Anti-Bacterial Agents Type of study: Prognostic_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article