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2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.
Neres, João; Hartkoorn, Ruben C; Chiarelli, Laurent R; Gadupudi, Ramakrishna; Pasca, Maria Rosalia; Mori, Giorgia; Venturelli, Alberto; Savina, Svetlana; Makarov, Vadim; Kolly, Gaelle S; Molteni, Elisabetta; Binda, Claudia; Dhar, Neeraj; Ferrari, Stefania; Brodin, Priscille; Delorme, Vincent; Landry, Valérie; de Jesus Lopes Ribeiro, Ana Luisa; Farina, Davide; Saxena, Puneet; Pojer, Florence; Carta, Antonio; Luciani, Rosaria; Porta, Alessio; Zanoni, Giuseppe; De Rossi, Edda; Costi, Maria Paola; Riccardi, Giovanna; Cole, Stewart T.
Affiliation
  • Neres J; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Hartkoorn RC; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • Chiarelli LR; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Gadupudi R; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • Pasca MR; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Mori G; §Department of Biology and Biotecnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Venturelli A; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy.
  • Savina S; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy.
  • Makarov V; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Kolly GS; §Department of Biology and Biotecnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Molteni E; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Binda C; §Department of Biology and Biotecnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Dhar N; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy.
  • Ferrari S; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Brodin P; #A. N. Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia.
  • Delorme V; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Landry V; #A. N. Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia.
  • de Jesus Lopes Ribeiro AL; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Farina D; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • Saxena P; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Pojer F; §Department of Biology and Biotecnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Carta A; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Luciani R; §Department of Biology and Biotecnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
  • Porta A; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Zanoni G; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • De Rossi E; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy.
  • Costi MP; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy.
  • Riccardi G; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).
  • Cole ST; ∇Inserm U1019 - CNRS UMR 8204, Institut Pasteur de Lille, Université de Lille, 1 rue du Professeur Calmette, 59019, Lille, France.
ACS Chem Biol ; 10(3): 705-14, 2015 Mar 20.
Article in En | MEDLINE | ID: mdl-25427196
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Full text: 1 Database: MEDLINE Main subject: Quinoxalines / Bacterial Proteins / Alcohol Oxidoreductases / Enzyme Inhibitors / Small Molecule Libraries / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: ACS Chem Biol Year: 2015 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Quinoxalines / Bacterial Proteins / Alcohol Oxidoreductases / Enzyme Inhibitors / Small Molecule Libraries / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: ACS Chem Biol Year: 2015 Type: Article