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Metabolic and inflammatory genes in schizophrenia.
Chase, Kayla A; Rosen, Cherise; Gin, Hannah; Bjorkquist, Olivia; Feiner, Benjamin; Marvin, Robert; Conrin, Sean; Sharma, Rajiv P.
Affiliation
  • Chase KA; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Rosen C; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Gin H; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Bjorkquist O; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Feiner B; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Marvin R; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Conrin S; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States.
  • Sharma RP; The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, United States; Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue (M/C 151), Chicago, IL 60612, United States. Electronic address: rsharma@psych.uic.edu.
Psychiatry Res ; 225(1-2): 208-211, 2015 Jan 30.
Article in En | MEDLINE | ID: mdl-25433960
ABSTRACT
Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.
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Full text: 1 Database: MEDLINE Main subject: Schizophrenia / CCAAT-Enhancer-Binding Proteins / PPAR alpha / PPAR gamma / Energy Metabolism / Overweight / Sterol Regulatory Element Binding Protein 1 Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Psychiatry Res Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Schizophrenia / CCAAT-Enhancer-Binding Proteins / PPAR alpha / PPAR gamma / Energy Metabolism / Overweight / Sterol Regulatory Element Binding Protein 1 Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Psychiatry Res Year: 2015 Type: Article Affiliation country: United States