cellPACK: a virtual mesoscope to model and visualize structural systems biology.
Nat Methods
; 12(1): 85-91, 2015 Jan.
Article
in En
| MEDLINE
| ID: mdl-25437435
ABSTRACT
cellPACK assembles computational models of the biological mesoscale, an intermediate scale (10-100 nm) between molecular and cellular biology scales. cellPACK's modular architecture unites existing and novel packing algorithms to generate, visualize and analyze comprehensive three-dimensional models of complex biological environments that integrate data from multiple experimental systems biology and structural biology sources. cellPACK is available as open-source code, with tools for validation of models and with 'recipes' and models for five biological systems blood plasma, cytoplasm, synaptic vesicles, HIV and a mycoplasma cell. We have applied cellPACK to model distributions of HIV envelope protein to test several hypotheses for consistency with experimental observations. Biologists, educators and outreach specialists can interact with cellPACK models, develop new recipes and perform packing experiments through scripting and graphical user interfaces at http//cellPACK.org/.
Full text:
1
Database:
MEDLINE
Main subject:
Algorithms
/
Systems Biology
/
Models, Biological
Type of study:
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Nat Methods
Journal subject:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2015
Type:
Article