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Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism.
Vanden Broeck, Lies; Kleinberger, Gernot; Chapuis, Julien; Gistelinck, Marc; Amouyel, Philippe; Van Broeckhoven, Christine; Lambert, Jean-Charles; Callaerts, Patrick; Dermaut, Bart.
Affiliation
  • Vanden Broeck L; Laboratory of Behavioral and Developmental Genetics, Center of Human Genetics, University of Leuven, Leuven, Belgium; VIB Center for the Biology of Disease, University of Leuven, Leuven, Belgium.
  • Kleinberger G; VIB Department of Molecular Genetics, Antwerpen, Belgium; Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.
  • Chapuis J; Inserm U744, Institut Pasteur de Lille, Université de Lille Nord de France, Lille, France.
  • Gistelinck M; Laboratory of Behavioral and Developmental Genetics, Center of Human Genetics, University of Leuven, Leuven, Belgium; VIB Center for the Biology of Disease, University of Leuven, Leuven, Belgium.
  • Amouyel P; Inserm U744, Institut Pasteur de Lille, Université de Lille Nord de France, Lille, France.
  • Van Broeckhoven C; VIB Department of Molecular Genetics, Antwerpen, Belgium; Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.
  • Lambert JC; Inserm U744, Institut Pasteur de Lille, Université de Lille Nord de France, Lille, France.
  • Callaerts P; Laboratory of Behavioral and Developmental Genetics, Center of Human Genetics, University of Leuven, Leuven, Belgium; VIB Center for the Biology of Disease, University of Leuven, Leuven, Belgium. Electronic address: patrick.callaerts@cme.vib-kuleuven.be.
  • Dermaut B; Inserm U744, Institut Pasteur de Lille, Université de Lille Nord de France, Lille, France; Center for Medical Genetics, Ghent University Hospital, Gent, Belgium. Electronic address: bart.dermaut@pasteur-lille.fr.
Neurobiol Aging ; 36(2): 1121-9, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25442115
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Full text: 1 Database: MEDLINE Main subject: Genetic Variation / DNA-Binding Proteins / Drosophila / Alzheimer Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Aging Year: 2015 Type: Article Affiliation country: Belgium
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Full text: 1 Database: MEDLINE Main subject: Genetic Variation / DNA-Binding Proteins / Drosophila / Alzheimer Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Aging Year: 2015 Type: Article Affiliation country: Belgium