Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK.

Bernsmeier, Christine; Pop, Oltin T; Singanayagam, Arjuna; Triantafyllou, Evangelos; Patel, Vishal C; Weston, Christopher J; Curbishley, Stuart; Sadiq, Fouzia; Vergis, Nikhil; Khamri, Wafa; Bernal, William; Auzinger, Georg; Heneghan, Michael; Ma, Yun; Jassem, Wayel; Heaton, Nigel D; Adams, David H; Quaglia, Alberto; Thursz, Mark R; Wendon, Julia; Antoniades, Charalambos G

Bernsmeier, Christine; Pop, Oltin T; Singanayagam, Arjuna; Triantafyllou, Evangelos; Patel, Vishal C; Weston, Christopher J; Curbishley, Stuart; Sadiq, Fouzia; Vergis, Nikhil; Khamri, Wafa; Bernal, William; Auzinger, Georg; Heneghan, Michael; Ma, Yun; Jassem, Wayel; Heaton, Nigel D; Adams, David H; Quaglia, Alberto; Thursz, Mark R; Wendon, Julia; Antoniades, Charalambos G.

Affiliation

Bernsmeier C; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Pop OT; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Singanayagam A; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Triantafyllou E; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom; Centre for Liver Research and National Institute for Health Research, Biomedical Research Unit, University of Birmingham, United Kingdom.
Patel VC; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Weston CJ; Centre for Liver Research and National Institute for Health Research, Biomedical Research Unit, University of Birmingham, United Kingdom.
Curbishley S; Centre for Liver Research and National Institute for Health Research, Biomedical Research Unit, University of Birmingham, United Kingdom.
Sadiq F; Section of Hepatology, St. Mary's Hospital, Imperial College London, United Kingdom.
Vergis N; Section of Hepatology, St. Mary's Hospital, Imperial College London, United Kingdom.
Khamri W; Section of Hepatology, St. Mary's Hospital, Imperial College London, United Kingdom.
Bernal W; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Auzinger G; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Heneghan M; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Ma Y; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Jassem W; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Heaton ND; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Adams DH; Centre for Liver Research and National Institute for Health Research, Biomedical Research Unit, University of Birmingham, United Kingdom.
Quaglia A; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Thursz MR; Section of Hepatology, St. Mary's Hospital, Imperial College London, United Kingdom.
Wendon J; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom.
Antoniades CG; Institute of Liver Studies, King's College Hospital, King's College London, United Kingdom; Centre for Liver Research and National Institute for Health Research, Biomedical Research Unit, University of Birmingham, United Kingdom; Section of Hepatology, St. Mary's Hospital, Imperial College London, U

Gastroenterology ; 148(3): 603-615.e14, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25479139

Subject(s)

Acute-On-Chronic Liver Failure/metabolism; End Stage Liver Disease/metabolism; Immunity, Innate/immunology; Liver Cirrhosis/metabolism; Liver Failure, Acute/metabolism; Liver/metabolism; Lymph Nodes/metabolism; Macrophages/metabolism; Monocytes/metabolism; Proto-Oncogene Proteins/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Acute-On-Chronic Liver Failure/immunology; Adult; Aged; End Stage Liver Disease/immunology; Female; Humans; Immunity, Innate/drug effects; Interleukin-6/metabolism; Lipopolysaccharides/pharmacology; Liver/drug effects; Liver/immunology; Liver Cirrhosis/immunology; Liver Failure, Acute/immunology; Lymph Nodes/immunology; Macrophages/drug effects; Macrophages/immunology; Male; Middle Aged; Monocytes/drug effects; Monocytes/immunology; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/immunology; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors; Receptor Protein-Tyrosine Kinases/immunology; Tumor Necrosis Factor-alpha/drug effects; Tumor Necrosis Factor-alpha/metabolism; c-Mer Tyrosine Kinase

Key words

ALF; Bacterial Infection; Immune Regulation; SIRS

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Full text: 1 Database: MEDLINE Main subject: Monocytes / Proto-Oncogene Proteins / Liver Failure, Acute / Receptor Protein-Tyrosine Kinases / End Stage Liver Disease / Acute-On-Chronic Liver Failure / Immunity, Innate / Liver / Liver Cirrhosis / Lymph Nodes Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Gastroenterology Year: 2015 Type: Article Affiliation country: United kingdom

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