IL-21 induction of CD4+ T cell differentiation into Th17 cells contributes to bleomycin-induced fibrosis in mice.

Lei, Ling; Zhong, Xiao-Ning; He, Zhi-Yi; Zhao, Cheng; Sun, Xue-Jiao

Lei, Ling; Zhong, Xiao-Ning; He, Zhi-Yi; Zhao, Cheng; Sun, Xue-Jiao.

Affiliation

Lei L; Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Cell Biol Int ; 39(4): 388-99, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25492803

Subject(s)

Bleomycin/toxicity; CD4-Positive T-Lymphocytes/cytology; Cell Differentiation/drug effects; Interleukins/pharmacology; Th17 Cells/cytology; Animals; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; Disease Models, Animal; Female; Fibrosis; Hydroxyproline/analysis; Interleukin-17/blood; Interleukin-17/genetics; Interleukin-17/metabolism; Interleukins/blood; Interleukins/genetics; Lung/metabolism; Lung/pathology; Mice; Mice, Inbred BALB C; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics; Recombinant Proteins/pharmacology; Scleroderma, Systemic/chemically induced; Scleroderma, Systemic/metabolism; Scleroderma, Systemic/pathology; Skin/metabolism; Skin/pathology; Th17 Cells/immunology; Up-Regulation/drug effects

Key words

CD4+ T cells; Th17 cells; interleukin-17; interleukin-21; systemic sclerosis

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Full text: 1 Database: MEDLINE Main subject: Bleomycin / CD4-Positive T-Lymphocytes / Cell Differentiation / Interleukins / Th17 Cells Limits: Animals Language: En Journal: Cell Biol Int Year: 2015 Type: Article Affiliation country: China

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