Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.

Wang, Yan-Dong; Chen, Wei-Dong; Li, Cunbao; Guo, Cong; Li, Yanyan; Qi, Hui; Shen, Hailing; Kong, Jing; Long, Xuecheng; Yuan, Frank; Wang, Xichun; Huang, Wendong

Wang, Yan-Dong; Chen, Wei-Dong; Li, Cunbao; Guo, Cong; Li, Yanyan; Qi, Hui; Shen, Hailing; Kong, Jing; Long, Xuecheng; Yuan, Frank; Wang, Xichun; Huang, Wendong.

Affiliation

Wang YD; State Key Laboratory of Chemical Resource Engineering (Y.-D.W., C.G., X.L.), College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China; Pathogenic Organisms and Immunology Lab (W.-D.C., C.L.), School of basic medical science, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia, People's Republic of China; Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery (W.D.C., Y.L., H.Q., H.S., J.K.), Scho

Mol Endocrinol ; 29(2): 322-31, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25496033

Subject(s)

Carcinogenesis/pathology; JNK Mitogen-Activated Protein Kinases/metabolism; Liver Neoplasms/enzymology; MAP Kinase Signaling System; Receptors, Cytoplasmic and Nuclear/metabolism; Superoxide Dismutase/metabolism; Animals; Antioxidants/metabolism; Base Sequence; Carcinogenesis/drug effects; Enzyme Activation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Hep G2 Cells; Hepatocytes/drug effects; Hepatocytes/metabolism; Hepatocytes/pathology; Humans; Isoxazoles/pharmacology; Liver/drug effects; Liver/metabolism; Liver/pathology; Liver Neoplasms/pathology; MAP Kinase Signaling System/drug effects; Male; Mice; Molecular Sequence Data; Oxidants/metabolism; Phosphorylation/drug effects; Promoter Regions, Genetic; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reactive Oxygen Species/metabolism; Receptors, Cytoplasmic and Nuclear/deficiency; Superoxide Dismutase/genetics; Up-Regulation/drug effects

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Full text: 1 Database: MEDLINE Main subject: Superoxide Dismutase / Receptors, Cytoplasmic and Nuclear / MAP Kinase Signaling System / JNK Mitogen-Activated Protein Kinases / Carcinogenesis / Liver Neoplasms Limits: Animals / Humans / Male Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2015 Type: Article

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