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The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Reshetnyak, Andrey V; Opatowsky, Yarden; Boggon, Titus J; Folta-Stogniew, Ewa; Tome, Francisco; Lax, Irit; Schlessinger, Joseph.
Affiliation
  • Reshetnyak AV; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Opatowsky Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Boggon TJ; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Folta-Stogniew E; The Biophysical Resource, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Tome F; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
  • Lax I; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: irit.lax@yale.edu.
  • Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: joseph.schlessinger@yale.edu.
Mol Cell ; 57(1): 191-201, 2015 Jan 08.
Article in En | MEDLINE | ID: mdl-25544564
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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins c-kit / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins c-kit / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2015 Type: Article Affiliation country: United States