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A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.
Kong, Bo; Wu, Weiwei; Cheng, Tao; Schlitter, Anna Melissa; Qian, Chengjia; Bruns, Philipp; Jian, Ziying; Jäger, Carsten; Regel, Ivonne; Raulefs, Susanne; Behler, Nora; Irmler, Martin; Beckers, Johannes; Friess, Helmut; Erkan, Mert; Siveke, Jens T; Tannapfel, Andrea; Hahn, Stephan A; Theis, Fabian J; Esposito, Irene; Kleeff, Jörg; Michalski, Christoph W.
Affiliation
  • Kong B; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Wu W; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Cheng T; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Schlitter AM; Institute of Pathology, TUM, Munich, Germany.
  • Qian C; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Bruns P; Department of Surgery, Technische Universität München (TUM), Munich, Germany Institute of Computational Biology, Helmholtz-Zentrum München, Munich, Germany.
  • Jian Z; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Jäger C; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Regel I; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Raulefs S; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Behler N; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Irmler M; Institute of Experimental Genetics (IEG), Helmholtz-Zentrum München, Munich, Germany.
  • Beckers J; Institute of Experimental Genetics (IEG), Helmholtz-Zentrum München, Munich, Germany Technische Universität München, Chair of Experimental Genetics, Freising, Germany Deutsches Zentrum für Diabetesforschung (DZD), Neuherberg, Germany.
  • Friess H; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Erkan M; Department of Surgery, Koc University School of Medicine, Istanbul, Turkey.
  • Siveke JT; Department of Gastroenterology, TUM, Munich, Germany.
  • Tannapfel A; Institute of Pathology, Ruhr-University Bochum, Bochum, Germany.
  • Hahn SA; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.
  • Theis FJ; Institute of Computational Biology, Helmholtz-Zentrum München, Munich, Germany.
  • Esposito I; Institute of Pathology, TUM, Munich, Germany.
  • Kleeff J; Department of Surgery, Technische Universität München (TUM), Munich, Germany.
  • Michalski CW; Department of Surgery, University of Heidelberg, Heidelberg, Germany.
Gut ; 65(4): 647-57, 2016 Apr.
Article in En | MEDLINE | ID: mdl-25601637
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Adenocarcinoma / Proto-Oncogene Proteins p21(ras) / MAP Kinase Signaling System / Carcinoma, Pancreatic Ductal / TOR Serine-Threonine Kinases / Carcinogenesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Gut Year: 2016 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Adenocarcinoma / Proto-Oncogene Proteins p21(ras) / MAP Kinase Signaling System / Carcinoma, Pancreatic Ductal / TOR Serine-Threonine Kinases / Carcinogenesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Gut Year: 2016 Type: Article Affiliation country: Germany