Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.

Li, Qingling; Deng, Shuang; Ibarra, Rafael A; Anderson, Vernon E; Brunengraber, Henri; Zhang, Guo-Fang

Li, Qingling; Deng, Shuang; Ibarra, Rafael A; Anderson, Vernon E; Brunengraber, Henri; Zhang, Guo-Fang.

Affiliation

Li Q; From the Departments of Nutrition and.
Deng S; From the Departments of Nutrition and.
Ibarra RA; From the Departments of Nutrition and.
Anderson VE; Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Brunengraber H; From the Departments of Nutrition and.
Zhang GF; From the Departments of Nutrition and gxz35@case.edu.

J Biol Chem ; 290(13): 8121-32, 2015 Mar 27.

Article in En | MEDLINE | ID: mdl-25645937

Subject(s)

Acetyl Coenzyme A/metabolism; Carnitine O-Acetyltransferase/metabolism; Myocardium/enzymology; Pyruvate Dehydrogenase Complex/metabolism; Animals; Carbon Isotopes/metabolism; Deuterium/metabolism; Glucose-6-Phosphate/metabolism; Glycolysis; In Vitro Techniques; Ketone Bodies/metabolism; Male; Rats, Sprague-Dawley; Tandem Mass Spectrometry

Key words

Acetoacetate; Acetyl Coenzyme A (Acetyl-CoA); Acetylcarnitine; Acetyltransferase; Cell Compartmentalization; Citric Acid Cycle; Glycolysis; Metabolic Channeling; Metabolomics; Substrate Cycling

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Full text: 1 Database: MEDLINE Main subject: Acetyl Coenzyme A / Pyruvate Dehydrogenase Complex / Carnitine O-Acetyltransferase / Myocardium Limits: Animals Language: En Journal: J Biol Chem Year: 2015 Type: Article

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