Synthesis and structure-activity relationship study of a new series of selective &#963;(1) receptor ligands for the treatment of pain: 4-aminotriazoles.

Díaz, José Luis; Christmann, Ute; Fernández, Ariadna; Torrens, Antoni; Port, Adriana; Pascual, Rosalia; Álvarez, Inés; Burgueño, Javier; Monroy, Xavier; Montero, Ana; Balada, Ariadna; Vela, José Miguel; Almansa, Carmen

Synthesis and structure-activity relationship study of a new series of selective σ(1) receptor ligands for the treatment of pain: 4-aminotriazoles.

Díaz, José Luis; Christmann, Ute; Fernández, Ariadna; Torrens, Antoni; Port, Adriana; Pascual, Rosalia; Álvarez, Inés; Burgueño, Javier; Monroy, Xavier; Montero, Ana; Balada, Ariadna; Vela, José Miguel; Almansa, Carmen.

Affiliation

Díaz JL; Drug Discovery and Preclinical Development, Esteve , Baldiri Reixach, 4-8, 08028 Barcelona, Spain.

J Med Chem ; 58(5): 2441-51, 2015 Mar 12.

Article in En | MEDLINE | ID: mdl-25658964

Subject(s)

Analgesics/chemical synthesis; Analgesics/pharmacology; Morpholines/chemical synthesis; Morpholines/pharmacology; Nociceptive Pain/drug therapy; Receptors, sigma/antagonists & inhibitors; Triazoles/chemical synthesis; Triazoles/pharmacology; Animals; Brain/drug effects; Cell Membrane/drug effects; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Guinea Pigs; HEK293 Cells; Humans; Male; Mice; Molecular Structure; Radioligand Assay; Structure-Activity Relationship; Sigma-1 Receptor

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Full text: 1 Database: MEDLINE Main subject: Triazoles / Morpholines / Receptors, sigma / Nociceptive Pain / Analgesics Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Type: Article Affiliation country: Spain

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