Glutathione, N-acetylcysteine and lipoic acid down-regulate starvation-induced apoptosis, RANKL/OPG ratio and sclerostin in osteocytes: involvement of JNK and ERK1/2 signalling.

Fontani, Filippo; Marcucci, Gemma; Iantomasi, Teresa; Brandi, Maria Luisa; Vincenzini, Maria Teresa

Fontani, Filippo; Marcucci, Gemma; Iantomasi, Teresa; Brandi, Maria Luisa; Vincenzini, Maria Teresa.

Affiliation

Fontani F; Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy.

Calcif Tissue Int ; 96(4): 335-46, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25660312

Subject(s)

Acetylcysteine/chemistry; Apoptosis; Glutathione/chemistry; Thioctic Acid/chemistry; Adaptor Proteins, Signal Transducing; Animals; Antioxidants/chemistry; Bone Diseases/metabolism; Bone Remodeling; Cell Line; Down-Regulation; Extracellular Signal-Regulated MAP Kinases/metabolism; Glycoproteins/metabolism; Hydrogen Peroxide/chemistry; Intercellular Signaling Peptides and Proteins; MAP Kinase Kinase 4/metabolism; Mice; Necrosis; Osteocytes/cytology; Osteoprotegerin/metabolism; Oxidation-Reduction; Phosphorylation; RANK Ligand/metabolism

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Full text: 1 Database: MEDLINE Main subject: Acetylcysteine / Thioctic Acid / Apoptosis / Glutathione Limits: Animals Language: En Journal: Calcif Tissue Int Year: 2015 Type: Article Affiliation country: Italy

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