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The Association of Elevated HDL Levels With Carotid Atherosclerosis in Middle-Aged Women With Untreated Essential Hypertension.
Triantafyllidi, Helen; Pavlidis, George; Trivilou, Paraskevi; Ikonomidis, Ignatios; Tzortzis, Stavros; Xenogiannis, Iosif; Schoinas, Antonios; Lekakis, John.
Affiliation
  • Triantafyllidi H; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece seliani@hotmail.com.
  • Pavlidis G; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
  • Trivilou P; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
  • Ikonomidis I; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
  • Tzortzis S; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
  • Xenogiannis I; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
  • Schoinas A; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
  • Lekakis J; Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
Angiology ; 66(10): 904-10, 2015 Nov.
Article in En | MEDLINE | ID: mdl-25694515
High-density lipoprotein cholesterol (HDL-C), a negative risk factor, is positively associated with a decreased risk of coronary heart disease. We investigated the association between high HDL-C levels and target organ damage (TOD) in never treated women with hypertension. We measured HDL-C levels in 117 women followed by estimation of TODs, that is, pulse wave velocity, microalbuminuria, left ventricular mass index, coronary flow reserve, and carotid intima-media thickness (cIMT). Women were divided into 2 groups (HDLH and HDLL), regarding HDL-C quartiles (upper quartile vs the first 3 lower quartiles). In HDLH group : HDL ≥70 mg/dL), cIMT was nonindependently, negatively related to HDL-C (ρ = -.42, P < .05). Using receiver -operating characteristic curve (ROC) analysis in the HDLH group, we concluded that the cutoff value of HDL ≥76.5 mg/dL moderately predicted the absence of carotid atherosclerosis (area under the curve: 0.77, P = .02; confidence interval: 0.57-0.97; sensitivity 73% and specificity 67%). Increased HDL-C may predict the absence of carotid atherosclerosis in middle-age women with untreated essential hypertension and consequently contribute to total cardiovascular risk estimation and treatment planning.
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Full text: 1 Database: MEDLINE Main subject: Carotid Artery Diseases / Hypertension / Cholesterol, HDL Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Angiology Year: 2015 Type: Article Affiliation country: Greece

Full text: 1 Database: MEDLINE Main subject: Carotid Artery Diseases / Hypertension / Cholesterol, HDL Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Angiology Year: 2015 Type: Article Affiliation country: Greece