Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease.

Pisonero-Vaquero, Sandra; Martínez-Ferreras, Ángel; García-Mediavilla, María Victoria; Martínez-Flórez, Susana; Fernández, Anna; Benet, Marta; Olcoz, José Luis; Jover, Ramiro; González-Gallego, Javier; Sánchez-Campos, Sonia

Pisonero-Vaquero, Sandra; Martínez-Ferreras, Ángel; García-Mediavilla, María Victoria; Martínez-Flórez, Susana; Fernández, Anna; Benet, Marta; Olcoz, José Luis; Jover, Ramiro; González-Gallego, Javier; Sánchez-Campos, Sonia.

Affiliation

Pisonero-Vaquero S; Institute of Biomedicine (IBIOMED), University of León, León, Spain.

Mol Nutr Food Res ; 59(5): 879-93, 2015 May.

Article in En | MEDLINE | ID: mdl-25712622

Subject(s)

Gene Expression Regulation/drug effects; Lipid Metabolism/drug effects; Non-alcoholic Fatty Liver Disease/drug therapy; Phosphatidylinositol 3-Kinases/physiology; Proto-Oncogene Proteins c-akt/physiology; Quercetin/pharmacology; Animals; CD36 Antigens/physiology; Cells, Cultured; Disease Models, Animal; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease/etiology; Non-alcoholic Fatty Liver Disease/metabolism; Oxidative Stress; Signal Transduction

Key words

Fatty acid uptake; Lipid metabolism; NAFLD; PI3K/AKT pathway; Quercetin

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Full text: 1 Database: MEDLINE Main subject: Quercetin / Gene Expression Regulation / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Lipid Metabolism / Non-alcoholic Fatty Liver Disease Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2015 Type: Article Affiliation country: Spain

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