ABSTRACT
BACKGROUND:
To investigate the effect of intra-abdominal volume increment (IAVI) on
intra-abdominal hypertension (IAH) in the
kidneys.
METHODS:
Eight
minipigs were successfully established as IAH models and were randomly divided into two groups the IAVI group and the sham-operated group. The intravesicular
pressure,
inferior vena cava pressure and
urine volume were measured before
shock, 2 h after IAH, and 22 h after
surgery, respectively. The following indices were measured
serum creatinine,
urea nitrogen, renal cortical thickness, ratio of abdominal anteroposterior diameter/transverse diameter, renal thickness, diameter of the renal sinus and the wet/dry ratio of renal
tissues.
RESULTS:
The intravesicular
pressure (IVP) of the 8
minipig IAH models was calculated to be 21.16 ± 4.63 mmHg. There was a significant increase in the abdominal anteroposterior diameter/transverse diameter ratio. The
minipigs in the IAVI group survived during the observational period, whereas 2
minipigs died at 18 h and 20 h in the sham-operated group. Twenty-two hours after
surgery, the
animals in the IAVI group displayed increased urinary volume (UV) and decreased Cr and Ur and remarkable decreases of VP and IVCP. After IAH, the renal cortical thickness and the renal thickness increased significantly. The renal wet/dry ratio in the sham-operated group was higher than that in the IAVI group.
CONCLUSION:
IAVI helps to control renal dysfunction after IAH, which may be related to lowering the intra-abdominal
pressure, thus alleviating renal
edema and
blood stasis.
