Ocular nerve growth factor administration counteracts the impairment of neural precursor cell viability and differentiation in the brain subventricular area of rats with streptozotocin-induced diabetes.

Tirassa, Paola; Maccarone, Mattia; Carito, Valentina; De Nicolò, Sara; Fiore, Marco

Tirassa, Paola; Maccarone, Mattia; Carito, Valentina; De Nicolò, Sara; Fiore, Marco.

Affiliation

Tirassa P; Institute of Cell Biology and Neurobiology, National Research Council (CNR), Via del Fosso di Fiorano, 64 (00143), Rome, Italy.

Eur J Neurosci ; 41(9): 1207-18, 2015 May.

Article in En | MEDLINE | ID: mdl-25728260

Subject(s)

Diabetes Mellitus, Experimental/drug therapy; Diabetic Retinopathy/drug therapy; Lateral Ventricles/drug effects; Nerve Growth Factor/therapeutic use; Neural Stem Cells/drug effects; Neurogenesis; Animals; Cell Survival; Doublecortin Domain Proteins; Doublecortin Protein; Glial Fibrillary Acidic Protein/genetics; Glial Fibrillary Acidic Protein/metabolism; Lateral Ventricles/cytology; Lateral Ventricles/metabolism; Male; Mice; Microtubule-Associated Proteins/genetics; Microtubule-Associated Proteins/metabolism; Nerve Growth Factor/administration & dosage; Nestin/genetics; Nestin/metabolism; Neural Cell Adhesion Molecules/genetics; Neural Cell Adhesion Molecules/metabolism; Neural Stem Cells/cytology; Neural Stem Cells/metabolism; Neuropeptides/genetics; Neuropeptides/metabolism; Protein Kinases/genetics; Protein Kinases/metabolism; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor/genetics; Receptor, Nerve Growth Factor/metabolism

Key words

brain pathology; collyrium; neurogenesis; neuroprotection; neurotrophins

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Full text: 1 Database: MEDLINE Main subject: Lateral Ventricles / Nerve Growth Factor / Diabetes Mellitus, Experimental / Diabetic Retinopathy / Neurogenesis / Neural Stem Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2015 Type: Article Affiliation country: Italy

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