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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.
Madison, J M; Zhou, F; Nigam, A; Hussain, A; Barker, D D; Nehme, R; van der Ven, K; Hsu, J; Wolf, P; Fleishman, M; O'Dushlaine, C; Rose, S; Chambert, K; Lau, F H; Ahfeldt, T; Rueckert, E H; Sheridan, S D; Fass, D M; Nemesh, J; Mullen, T E; Daheron, L; McCarroll, S; Sklar, P; Perlis, R H; Haggarty, S J.
Affiliation
  • Madison JM; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA [3] Department of Psychiatry, Massachusetts General Hospital, B
  • Zhou F; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA.
  • Nigam A; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Hussain A; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA.
  • Barker DD; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Nehme R; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • van der Ven K; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA.
  • Hsu J; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA.
  • Wolf P; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA [3] Department of Neurology, Massachusetts General Hospital and
  • Fleishman M; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA.
  • O'Dushlaine C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rose S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chambert K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lau FH; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Ahfeldt T; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Rueckert EH; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA [3] Chemical Neurobiology Laboratory, Center for Human Genetic
  • Sheridan SD; Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
  • Fass DM; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA [3] Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Ho
  • Nemesh J; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Mullen TE; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Daheron L; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • McCarroll S; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Sklar P; 1] Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA [2] Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Perlis RH; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA [3] Department of Psychiatry, Massachusetts General Hospital, B
  • Haggarty SJ; 1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA [3] Department of Psychiatry, Massachusetts General Hospital, B
Mol Psychiatry ; 20(6): 703-17, 2015 Jun.
Article in En | MEDLINE | ID: mdl-25733313
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Full text: 1 Database: MEDLINE Main subject: Bipolar Disorder / RNA, Messenger / Gene Expression / Receptors, CXCR4 / Induced Pluripotent Stem Cells / Neurons Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2015 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Bipolar Disorder / RNA, Messenger / Gene Expression / Receptors, CXCR4 / Induced Pluripotent Stem Cells / Neurons Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2015 Type: Article