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Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques.
Evgin, Laura; Acuna, Sergio A; Tanese de Souza, Christiano; Marguerie, Monique; Lemay, Chantal G; Ilkow, Carolina S; Findlay, C Scott; Falls, Theresa; Parato, Kelley A; Hanwell, David; Goldstein, Alyssa; Lopez, Roberto; Lafrance, Sandra; Breitbach, Caroline J; Kirn, David; Atkins, Harold; Auer, Rebecca C; Thurman, Joshua M; Stahl, Gregory L; Lambris, John D; Bell, John C; McCart, J Andrea.
Affiliation
  • Evgin L; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Acuna SA; Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Tanese de Souza C; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Marguerie M; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Lemay CG; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Ilkow CS; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Findlay CS; Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.
  • Falls T; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Parato KA; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Hanwell D; Animal Resources Centre, University Health Network, Toronto, Ontario, Canada.
  • Goldstein A; Animal Resources Centre, University Health Network, Toronto, Ontario, Canada.
  • Lopez R; Animal Resources Centre, University Health Network, Toronto, Ontario, Canada.
  • Lafrance S; Animal Resources Centre, University Health Network, Toronto, Ontario, Canada.
  • Breitbach CJ; SillaJen Inc., Seoul, South Korea.
  • Kirn D; SillaJen Inc., Seoul, South Korea.
  • Atkins H; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Auer RC; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
  • Thurman JM; Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
  • Stahl GL; Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, USA.
  • Lambris JD; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bell JC; Center for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: jbell@ohri.ca.
  • McCart JA; Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Surgery, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
Mol Ther ; 23(6): 1066-1076, 2015 Jun.
Article in En | MEDLINE | ID: mdl-25807289
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Full text: 1 Database: MEDLINE Main subject: Vaccinia virus / Oncolytic Viruses / Oncolytic Virotherapy Limits: Animals / Female / Humans / Male Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2015 Type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Vaccinia virus / Oncolytic Viruses / Oncolytic Virotherapy Limits: Animals / Female / Humans / Male Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2015 Type: Article Affiliation country: Canada