A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.

Maruani, Antoine; Smith, Mark E B; Miranda, Enrique; Chester, Kerry A; Chudasama, Vijay; Caddick, Stephen

Maruani, Antoine; Smith, Mark E B; Miranda, Enrique; Chester, Kerry A; Chudasama, Vijay; Caddick, Stephen.

Affiliation

Maruani A; Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK.
Smith ME; Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK.
Miranda E; UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK.
Chester KA; UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK.
Chudasama V; Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK.
Caddick S; Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK.

Nat Commun ; 6: 6645, 2015 Mar 31.

Article in En | MEDLINE | ID: mdl-25824906

Subject(s)

Antibodies/chemistry; Antineoplastic Agents/chemistry; Breast Neoplasms/drug therapy; Drug Delivery Systems/methods; Immunoconjugates/chemistry; Trastuzumab/chemistry; Antibodies/therapeutic use; Antineoplastic Agents/administration & dosage; Breast Neoplasms/metabolism; Cell Line, Tumor; Chromatography, Liquid; Click Chemistry; Electrophoresis, Polyacrylamide Gel; Humans; Immunoconjugates/therapeutic use; Mass Spectrometry; Microscopy, Confocal; Photoelectron Spectroscopy; Receptor, ErbB-2/metabolism; Trastuzumab/administration & dosage

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Drug Delivery Systems / Immunoconjugates / Trastuzumab / Antibodies / Antineoplastic Agents Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2015 Type: Article Affiliation country: United kingdom

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