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The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Vicuña, Lucas; Strochlic, David E; Latremoliere, Alban; Bali, Kiran Kumar; Simonetti, Manuela; Husainie, Dewi; Prokosch, Sandra; Riva, Priscilla; Griffin, Robert S; Njoo, Christian; Gehrig, Stefanie; Mall, Marcus A; Arnold, Bernd; Devor, Marshall; Woolf, Clifford J; Liberles, Stephen D; Costigan, Michael; Kuner, Rohini.
Affiliation
  • Vicuña L; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
  • Strochlic DE; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
  • Latremoliere A; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Bali KK; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
  • Simonetti M; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
  • Husainie D; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
  • Prokosch S; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
  • Riva P; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Griffin RS; Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA.
  • Njoo C; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
  • Gehrig S; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.
  • Mall MA; Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.
  • Arnold B; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
  • Devor M; Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Woolf CJ; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Liberles SD; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
  • Costigan M; 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Kuner R; Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
Nat Med ; 21(5): 518-23, 2015 May.
Article in En | MEDLINE | ID: mdl-25915831
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Full text: 1 Database: MEDLINE Main subject: Acute-Phase Proteins / T-Lymphocytes / Serpins / Leukocyte Elastase / Enzyme Inhibitors Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2015 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Acute-Phase Proteins / T-Lymphocytes / Serpins / Leukocyte Elastase / Enzyme Inhibitors Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2015 Type: Article Affiliation country: Germany