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A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.
Wootla, Bharath; Denic, Aleksandar; Watzlawik, Jens O; Warrington, Arthur E; Rodriguez, Moses.
Affiliation
  • Wootla B; Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Wootla.Bharath@mayo.edu.
  • Denic A; Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Denic.Aleksandar@mayo.edu.
  • Watzlawik JO; Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Watzlawik.Jens@mayo.edu.
  • Warrington AE; Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Warrington.Arthur@mayo.edu.
  • Rodriguez M; Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Rodriguez.Moses@mayo.edu.
J Neuroinflammation ; 12: 83, 2015 Apr 29.
Article in En | MEDLINE | ID: mdl-25924771
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Full text: 1 Database: MEDLINE Main subject: Brain Stem / Membrane Glycoproteins / Viral Envelope Proteins / Aspartic Acid / Antibodies, Monoclonal / Multiple Sclerosis Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Brain Stem / Membrane Glycoproteins / Viral Envelope Proteins / Aspartic Acid / Antibodies, Monoclonal / Multiple Sclerosis Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2015 Type: Article Affiliation country: United States