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Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment.
Yamada, Hisatsugu; Hasegawa, Yoshinori; Suzuki, Yuki; Imai, Hirohiko; Matsuda, Tetsuya; Kimura, Yu; Toshimitsu, Akio; Aoyama, Yasuhiro; Kondo, Teruyuki.
Affiliation
  • Yamada H; Advanced Biomedical Engineering Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Hasegawa Y; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Suzuki Y; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Imai H; Department of Systems Science, Graduate School of Informatics, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan.
  • Matsuda T; Department of Systems Science, Graduate School of Informatics, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan.
  • Kimura Y; Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Toshimitsu A; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan; Division of Multidisciplinary Chemistry, Institute for Chemical Research, Kyoto University, Gokanosho, Uji, Kyoto 611-0011, Japan.
  • Aoyama Y; Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. Electronic address: aoyama.yasuhiro.78z@st.kyoto-u.ac.jp.
  • Kondo T; Advanced Biomedical Engineering Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku,
Bioorg Med Chem Lett ; 25(13): 2675-8, 2015 Jul 01.
Article in En | MEDLINE | ID: mdl-25958246
A (13)C-enriched phosphorylcholine polymer ((13)C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(-) (pancreatic) tumors, the antibody-tag conjugate (13)C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the (1)H-(13)C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged.
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Stomach Neoplasms / Immunoconjugates Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Stomach Neoplasms / Immunoconjugates Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Type: Article Affiliation country: Japan