Association between sex, systemic iron variation and probability of Parkinson's disease.
Int J Neurosci
; 126(4): 354-60, 2016.
Article
in En
| MEDLINE
| ID: mdl-26000822
ABSTRACT
OBJECTIVE:
Iron homeostasis appears altered in Parkinson's disease (PD). Recent genetic studies and meta-analyses have produced heterogeneous and inconclusive results. In order to verify the possible role of iron status in PD, we have screened some of the main metal gene variants, evaluated their effects on iron systemic status, and checked for possible interactions with PD. MATERIALS ANDMETHODS:
In 92 PD patients and 112 healthy controls, we screened the D544E and R793H variants of the ceruloplasmin gene (CP), the P589S variant of the transferrin gene (TF), and the H63D and C282Y variants of the HFE gene, encoding for homologous proteins, respectively. Furthermore, we analyzed serum concentrations of iron, copper and their related proteins.RESULTS:
The genetic investigation revealed no significant differences in allelic and genotype distributions between patients and controls. Two different multivariable forward stepwise logistic models showed that, when the effect of sex is considered, an increase of the probability of having PD is associated with low iron concentration and Tf-saturation.CONCLUSIONS:
This study provides new evidence of the involvement of iron metabolism in PD pathogenesis and reveals a biological effect of sex.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Ceruloplasmin
/
Transferrin
/
Hemochromatosis Protein
/
Iron
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Neurosci
Year:
2016
Type:
Article
Affiliation country:
Italy