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A genomewide association mapping study using ultrasound-scanned information identifies potential genomic regions and candidate genes affecting carcass traits in Nellore cattle.
Santana, M H A; Ventura, R V; Utsunomiya, Y T; Neves, H H R; Alexandre, P A; Oliveira Junior, G A; Gomes, R C; Bonin, M N; Coutinho, L L; Garcia, J F; Silva, S L; Fukumasu, H; Leme, P R; Ferraz, J B S.
Affiliation
  • Santana MH; Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
  • Ventura RV; Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
  • Utsunomiya YT; Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.
  • Neves HH; Beef Improvement Opportunties (BIO), Guelph, ON, Canada.
  • Alexandre PA; Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, Brazil.
  • Oliveira Junior GA; Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, Brazil.
  • Gomes RC; GenSys Consultores Associados S/C Ltda, Porto Alegre, Brazil.
  • Bonin MN; Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
  • Coutinho LL; Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
  • Garcia JF; Empresa Brasileira de Pesquisa Agropecuária, CNPGC/EMBRAPA, Campo Grande, Brazil.
  • Silva SL; Empresa Brasileira de Pesquisa Agropecuária, CNPGC/EMBRAPA, Campo Grande, Brazil.
  • Fukumasu H; Escola Superior de Agricultura Luiz de Queiroz, USP, Piracicaba, Brazil.
  • Leme PR; Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, Brazil.
  • Ferraz JB; Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
J Anim Breed Genet ; 132(6): 420-7, 2015 Dec.
Article in En | MEDLINE | ID: mdl-26016521
ABSTRACT
The aim of this study was to identify candidate genes and genomic regions associated with ultrasound-derived measurements of the rib-eye area (REA), backfat thickness (BFT) and rumpfat thickness (RFT) in Nellore cattle. Data from 640 Nellore steers and young bulls with genotypes for 290 863 single nucleotide polymorphisms (SNPs) were used for genomewide association mapping. Significant SNP associations were explored to find possible candidate genes related to physiological processes. Several of the significant markers detected were mapped onto functional candidate genes including ARFGAP3, CLSTN2 and DPYD for REA; OSBPL3 and SUDS3 for BFT; and RARRES1 and VEPH1 for RFT. The physiological pathway related to lipid metabolism (CLSTN2, OSBPL3, RARRES1 and VEPH1) was identified. The significant markers within previously reported QTLs reinforce the importance of the genomic regions, and the other loci offer candidate genes that have not been related to carcass traits in previous investigations.
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Full text: 1 Database: MEDLINE Main subject: Cattle / Adipose Tissue / Quantitative Trait Loci / Body Fat Distribution / Lipid Metabolism / Red Meat Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Anim Breed Genet Journal subject: GENETICA / MEDICINA VETERINARIA Year: 2015 Type: Article Affiliation country: Brazil
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Full text: 1 Database: MEDLINE Main subject: Cattle / Adipose Tissue / Quantitative Trait Loci / Body Fat Distribution / Lipid Metabolism / Red Meat Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Anim Breed Genet Journal subject: GENETICA / MEDICINA VETERINARIA Year: 2015 Type: Article Affiliation country: Brazil