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The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats.
Guven, Mustafa; Yuksel, Yasemin; Sehitoglu, Muserref Hilal; Tokmak, Mehmet; Aras, Adem Bozkurt; Akman, Tarik; Golge, Umut Hatay; Goksel, Ferdi; Karavelioglu, Ergun; Cosar, Murat.
Affiliation
  • Guven M; Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. drmustafaguven@comu.edu.tr.
  • Yuksel Y; Department of Histology & Embryology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
  • Sehitoglu MH; Department of Medical Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
  • Tokmak M; Department of Neurosurgery, Faculty of Medicine, Medipol University, Istanbul, Turkey.
  • Aras AB; Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
  • Akman T; Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
  • Golge UH; Department of Orthopaedic, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
  • Goksel F; Department of Orthopaedic, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
  • Karavelioglu E; Department of Neurosurgery, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
  • Cosar M; Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Inflammation ; 38(6): 2124-32, 2015 Dec.
Article in En | MEDLINE | ID: mdl-26049410
The aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemia was achieved by abdominal aorta clamping, and all animals were sacrificed 24 h after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and methylprednisolone when compared to the corresponding untreated group (p < 0.05). Ischemic fiber degeneration significantly reduced in the SNI + CA and SNI + MP groups, especially in the SNI + MP group, compared to the SNI group (p < 0.05). Beta amyloid protein expressions were significantly decreased in the SNI + CA group compared to the SNI group (p < 0.05). Our study revealed that coumaric acid treatment after ischemia/reperfusion in rat sciatic nerves reduced oxidative stress and axonal degeneration. Therefore, coumaric acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
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Full text: 1 Database: MEDLINE Main subject: Sciatic Nerve / Reperfusion Injury / Neuroprotective Agents / Coumaric Acids / Sciatic Neuropathy / Peripheral Nerve Injuries Type of study: Prognostic_studies Limits: Animals Language: En Journal: Inflammation Year: 2015 Type: Article Affiliation country: Turkey
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Full text: 1 Database: MEDLINE Main subject: Sciatic Nerve / Reperfusion Injury / Neuroprotective Agents / Coumaric Acids / Sciatic Neuropathy / Peripheral Nerve Injuries Type of study: Prognostic_studies Limits: Animals Language: En Journal: Inflammation Year: 2015 Type: Article Affiliation country: Turkey