Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions.

Wang, Ze-Jun; Tabakoff, Boris; Levinson, Simon R; Heinbockel, Thomas

Wang, Ze-Jun; Tabakoff, Boris; Levinson, Simon R; Heinbockel, Thomas.

Affiliation

Wang ZJ; Department of Anatomy, Howard University College of Medicine, Washington 20059, DC, USA.
Tabakoff B; Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora 80045, CO, USA.
Levinson SR; Department of Physiology and Biophysics, University of Colorado Denver School of Medicine, Aurora 80045, CO, USA.
Heinbockel T; Department of Anatomy, Howard University College of Medicine, Washington 20059, DC, USA.

Acta Pharmacol Sin ; 36(7): 791-9, 2015 Jul.

Article in En | MEDLINE | ID: mdl-26051112

Subject(s)

Analgesics/pharmacology; Anesthetics/pharmacology; Eugenol/analogs & derivatives; NAV1.7 Voltage-Gated Sodium Channel/physiology; Sodium Channel Blockers/pharmacology; Animals; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Eugenol/pharmacology; Humans

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Full text: 1 Database: MEDLINE Main subject: Eugenol / Sodium Channel Blockers / NAV1.7 Voltage-Gated Sodium Channel / Analgesics / Anesthetics Limits: Animals / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2015 Type: Article Affiliation country: United States

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