Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice.

Byon, Chang Hyun; Han, Tieyan; Wu, Judy; Hui, Simon T

Byon, Chang Hyun; Han, Tieyan; Wu, Judy; Hui, Simon T.

Affiliation

Byon CH; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Han T; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Wu J; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Hui ST; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sthui@mednet.ucla.edu.

Atherosclerosis ; 241(2): 313-21, 2015 Aug.

Article in En | MEDLINE | ID: mdl-26062991

Subject(s)

Aortic Diseases/prevention & control; Apolipoproteins E/deficiency; Atherosclerosis/prevention & control; Carrier Proteins/metabolism; Inflammation/prevention & control; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Thioredoxins/metabolism; Animals; Aorta, Abdominal/metabolism; Aorta, Abdominal/pathology; Aortic Diseases/genetics; Aortic Diseases/metabolism; Aortic Diseases/pathology; Apolipoproteins E/genetics; Atherosclerosis/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; Carrier Proteins/genetics; Cell Adhesion; Cell Adhesion Molecules/metabolism; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Hydrogen Peroxide/pharmacology; Inflammation/genetics; Inflammation/metabolism; Inflammation/pathology; Inflammation Mediators/metabolism; Macrophages/metabolism; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/pathology; NF-kappa B/metabolism; Oxidation-Reduction; Oxidative Stress; Plaque, Atherosclerotic; Signal Transduction/drug effects; Thioredoxins/genetics

Key words

Atherosclerosis; Inflammation; Oxidative stress

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Full text: 1 Database: MEDLINE Main subject: Aortic Diseases / Apolipoproteins E / Thioredoxins / Carrier Proteins / Myocytes, Smooth Muscle / Atherosclerosis / Inflammation / Muscle, Smooth, Vascular Type of study: Prognostic_studies Language: En Journal: Atherosclerosis Year: 2015 Type: Article Affiliation country: United States

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