Amidation inhibitors 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester are novel HDAC inhibitors with anti-tumorigenic properties.

Ali, Amna; Burns, Timothy J; Lucrezi, Jacob D; May, Sheldon W; Green, George R; Matesic, Diane F

Ali, Amna; Burns, Timothy J; Lucrezi, Jacob D; May, Sheldon W; Green, George R; Matesic, Diane F.

Affiliation

Ali A; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA, 30341, USA.

Invest New Drugs ; 33(4): 827-34, 2015 Aug.

Article in En | MEDLINE | ID: mdl-26065689

Subject(s)

Antineoplastic Agents/pharmacology; Caproates/pharmacology; Fatty Acids, Monounsaturated/pharmacology; Histone Deacetylase Inhibitors/pharmacology; Animals; Cell Line; Cell Line, Tumor; Histone Deacetylases/metabolism; Humans; Hydroxamic Acids/pharmacology; Models, Molecular; Rats; Vorinostat

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Full text: 1 Database: MEDLINE Main subject: Caproates / Fatty Acids, Monounsaturated / Histone Deacetylase Inhibitors / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Invest New Drugs Year: 2015 Type: Article Affiliation country: United States

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