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Development of an intein-mediated split-Cas9 system for gene therapy.
Truong, Dong-Jiunn Jeffery; Kühner, Karin; Kühn, Ralf; Werfel, Stanislas; Engelhardt, Stefan; Wurst, Wolfgang; Ortiz, Oskar.
Affiliation
  • Truong DJ; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 85764, Germany Institute of Developmental Genetics,Technische Universität München, Freising-Weihenstephan 85354, Germany.
  • Kühner K; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 85764, Germany.
  • Kühn R; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 85764, Germany Max Delbrück Center for Molecular Medicine (MDC), Berlin 13125, Germany.
  • Werfel S; Institute of Pharmacology and Toxicology. Technische Universität München, Munich 80802, Germany.
  • Engelhardt S; Institute of Pharmacology and Toxicology. Technische Universität München, Munich 80802, Germany German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich 80802, Germany.
  • Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 85764, Germany Institute of Developmental Genetics,Technische Universität München, Freising-Weihenstephan 85354, Germany Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
  • Ortiz O; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 85764, Germany oskar.ortiz@helmholtz-muenchen.de.
Nucleic Acids Res ; 43(13): 6450-8, 2015 Jul 27.
Article in En | MEDLINE | ID: mdl-26082496
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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / Deoxyribonucleases / Inteins / CRISPR-Associated Proteins / CRISPR-Cas Systems Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2015 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / Deoxyribonucleases / Inteins / CRISPR-Associated Proteins / CRISPR-Cas Systems Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2015 Type: Article Affiliation country: Germany