Aerobic exercise training reduces cardiac function in adult male offspring exposed to prenatal hypoxia.
Am J Physiol Regul Integr Comp Physiol
; 309(5): R489-98, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-26157059
ABSTRACT
Intrauterine growth restriction (IUGR) has been associated with increased susceptibility to myocardial ischemia-reperfusion (I/R) injury. Exercise is an effective preventive intervention for cardiovascular diseases; however, it may be detrimental in conditions of compromised health. The aim of this study was to determine whether exercise training can improve cardiac performance after I/R injury in IUGR offspring. We used a hypoxia-induced IUGR model by exposing pregnant Sprague-Dawley rats to 21% oxygen (control) or hypoxic (11% oxygen; IUGR) conditions from gestational day 15 to 21. At 10 wk of age, offspring were randomized to a sedentary group or to a 6-wk exercise protocol. Transthoracic echocardiography assessments were performed after 6 wk. Twenty-four hours after the last bout of exercise, ex vivo cardiac function was determined using a working heart preparation. With exercise training, there was improved baseline cardiac performance in male control offspring but a reduced baseline cardiac performance in male IUGR exercised offspring (P < 0.05). In male offspring, exercise decreased superoxide generation in control offspring, while in IUGR offspring, it had the polar opposite effect (interaction P ≤ 0.05). There was no effect of IUGR or exercise on cardiac function in female offspring. In conclusion, in male IUGR offspring, exercise may be a secondary stressor on cardiac function. A reduction in cardiac performance along with an increase in superoxide production in response to exercise was observed in this susceptible group.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Myocardial Reperfusion Injury
/
Ventricular Function, Left
/
Physical Exertion
/
Fetal Hypoxia
/
Fetal Growth Retardation
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Am J Physiol Regul Integr Comp Physiol
Journal subject:
FISIOLOGIA
Year:
2015
Type:
Article
Affiliation country:
Canada