RIPping the Skin Apart: Necroptosis Signaling in Toxic Epidermal Necrolysis.
J Invest Dermatol
; 135(8): 1940-1943, 2015 Aug.
Article
in En
| MEDLINE
| ID: mdl-26174536
ABSTRACT
Toxic epidermal necrolysis (TEN) is a rare but potentially fatal drug hypersensitivity reaction. Although a number of pathophysiological hints have been identified over the past decade, details of the effector mechanisms within the skin remain obscure. A novel study by Kim et al. now sheds light on its pathophysiology. The investigators demonstrate convincingly that receptor-interacting kinase 3 (RIPK3) levels are upregulated substantially in the lesional skin of patients with TEN and that this is followed by the generation of reactive oxygen species, activation of mixed lineage kinase-like protein, and subsequent necroptotic cell death of keratinocytes. These data suggest that therapies that interfere with RIPK3 activation and necroptosis induction could benefit patients with TEN.
Full text:
1
Database:
MEDLINE
Main subject:
Protein Kinases
/
Up-Regulation
/
Stevens-Johnson Syndrome
/
Epidermis
/
Receptor-Interacting Protein Serine-Threonine Kinases
Limits:
Humans
Language:
En
Journal:
J Invest Dermatol
Year:
2015
Type:
Article
Affiliation country:
Germany