The Effect of Silibinin on the Pharmacokinetics of Ivabradine and N-Desmethylivabradine in Rats.

Chen, Xing-Peng; Zheng, Hai-Tao; Cai, Wei-Wei; Li, Meng-Ke; Zhang, Jian-Wei; Hu, Jie

Chen, Xing-Peng; Zheng, Hai-Tao; Cai, Wei-Wei; Li, Meng-Ke; Zhang, Jian-Wei; Hu, Jie.

Affiliation

Chen XP; Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, PR China.

Pharmacology ; 96(3-4): 107-11, 2015.

Article in En | MEDLINE | ID: mdl-26202095

Subject(s)

Antioxidants/pharmacology; Benzazepines/pharmacokinetics; Cardiotonic Agents/pharmacokinetics; Silymarin/pharmacology; Animals; Area Under Curve; Biotransformation; Drug Interactions; Half-Life; Ivabradine; Male; Rats; Rats, Sprague-Dawley; Silybin

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Full text: 1 Database: MEDLINE Main subject: Silymarin / Benzazepines / Cardiotonic Agents / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharmacology Year: 2015 Type: Article

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